AEWS0031

NCT00006734 📎

Regimen

Experimental
VDC/IE every 2 weeks (interval compression with G-CSF support)
Control
VDC/IE every 3 weeks (standard)

Population

Newly diagnosed localized Ewing sarcoma family of tumors, age <50

Key finding

Simply giving the same chemotherapy more frequently improved EFS by 8 percentage points without increased toxicity. Established dose-dense VDC/IE q2w as the North American standard for localized Ewing.

Source: PMID 23091096

Timeline

    Guideline citations

    • NCCN BONE (p.65)