POG-8651

Regimen

Experimental
Pre-surgical (neoadjuvant) chemotherapy followed by surgery and adjuvant chemotherapy
Control
Immediate surgery followed by identical adjuvant chemotherapy

Population

Non-metastatic high-grade osteosarcoma of extremity, age <=30

Key finding

Neoadjuvant timing did NOT change survival — but it enabled limb-sparing surgery and histologic response assessment, which then became a prognostic and stratification tool. The 'neoadjuvant chemo is standard' dogma is based on surgical feasibility, not a survival RCT.

Source: PMID 12697883

Timeline

    Guideline citations

    • NCCN BONE (p.110)