IWWD

Regimen

Experimental
Watch-and-wait (non-operative management) after achieving clinical complete response (cCR)
Control
Historical control (no concurrent control arm)

Population

Rectal cancer patients with clinical complete response (cCR) after neoadjuvant treatment (N=880, 47 institutions, 15 countries); registry/observational.

Key finding

2-year local regrowth rate 25.2%; nearly all regrowths (97%) occur within 3 years. Salvage surgery feasible in 88% of regrowths. 5-year OS 85% for watch-and-wait cCR patients. Non-operative management is feasible for selected patients achieving cCR, with intensive surveillance required.

Source: PMID 29976470

Timeline

    Guideline citations

    • NCCN Rectal (p.115)