CHECKMATE-577
Regimen
- Experimental
- nivolumab (adjuvant)
- Control
- placebo
Population
Resected (R0) stage II/III esophageal or GEJ cancer with residual pathological disease after neoadjuvant chemoradiotherapy
Key finding
mDFS 22.4 vs 11.0 mo (HR 0.69, 96.4% CI 0.56-0.86, P<0.001). Approved globally as SoC adjuvant for non-pCR EC/GEJ post-neoadj CRT.
Source: PMID 33789008
Timeline
Guideline citations
- NCCN ESOPHAGEAL (p.119)