FREGAT-SALVAGE-COHORT

Regimen

Experimental
salvage esophagectomy (SALV) after definitive chemoradiotherapy
Control
neoadjuvant CRT with planned esophagectomy (NCRS)

Population

Esophageal cancer undergoing resection at 30 European centres 2000-2010 (propensity-matched cohort)

Key finding

After matching, 3y OS SALV 43.3% vs NCRS 40.1% (NS); in-hospital mortality similar (8.4% vs 9.3%); higher leak rate with SALV (17.2% vs 10.7%).

Source: PMID 26195702

Timeline

    Guideline citations

    • NCCN ESOPHAGEAL (p.39)