KEYNOTE-975

NCT04210115 📎

Regimen

Experimental
pembrolizumab + definitive chemoradiotherapy
Control
placebo + definitive chemoradiotherapy

Population

Locally advanced unresectable esophageal or GEJ cancer, first-line (design paper; trial ongoing)

Key finding

Design paper only; OS/EFS dual primary endpoints. Enrollment completed; results awaited as of early 2026.

Source: PMID 33533655

Timeline