PBT-VS-IMRT-(LIN)

NCT01512589 📎

Regimen

Experimental
proton beam therapy (PBT) 50.4 Gy + concurrent chemotherapy
Control
intensity-modulated radiation therapy (IMRT) 50.4 Gy + concurrent chemotherapy

Population

Locally advanced esophageal cancer treated with definitive or neoadjuvant chemoradiotherapy

Key finding

Mean TTB 2.3× lower with PBT (17.4 vs 39.9); postop complication score 7.6× lower with PBT (2.5 vs 19.1); 3y PFS and OS similar (~50% / 44.5%).

Source: PMID 32160096

Timeline

    Guideline citations

    • NCCN ESOPHAGEAL (p.71)