NEO-AEGIS
Regimen
- Experimental
- neoadjuvant chemoradiotherapy (CROSS regimen) + surgery
- Control
- perioperative chemotherapy (MAGIC or FLOT) + surgery
Population
Locally advanced resectable oesophageal or EGJ adenocarcinoma
Key finding
mOS 48 vs 49.2 mo (HR 1.03, 95% CI 0.77-1.38, p=0.82); 3y OS 55% vs 57%; pCR + R0 favored CRT; DFS HR 0.89 (NS)
Source: PMID 37734399
Timeline
Guideline citations
- CSCO GASTRIC 2025 (p.77)⚠️ OCR source