TOPGEAR
Regimen
- Experimental
- preoperative chemoradiotherapy + perioperative chemotherapy (ECF or FLOT)
- Control
- perioperative chemotherapy alone (ECF or FLOT)
Population
Resectable stomach or GEJ adenocarcinoma
Key finding
pCR 17% vs 8% favoring CRT; median OS 46 vs 49 mo (HR 1.05, 95% CI 0.83-1.31, NS); mPFS 31 vs 32 mo (NS)
Source: PMID 39282905
Timeline
Guideline citations
- NCCN GASTRIC (p.85)
- CSCO GASTRIC 2025 (p.67)⚠️ OCR source