LIGHT-(LINIFANIB)

NCT01009593 📎

Regimen

Experimental
linifanib 17.5 mg/day
Control
sorafenib

Population

Advanced hepatocellular carcinoma, no prior systemic therapy

Key finding

mOS 9.1 linifanib vs 9.8 sorafenib (HR 1.046, 95% CI 0.896-1.221); superiority/noninferiority both NOT met; linifanib higher toxicity burden (grade 3/4 AEs, SAEs, discontinuation all P<0.001 worse)

Source: PMID 25488963

Timeline