CREST

Regimen

Experimental
Thoracic radiotherapy 30 Gy in 10 fractions + PCI, after chemotherapy response
Control
No thoracic radiotherapy, PCI only, after chemotherapy response

Population

Extensive-stage SCLC, WHO PS 0-2, responded to chemotherapy

Key finding

1-yr OS 33% (TRT) vs 28% (control), HR 0.84 (95% CI 0.69-1.01, p=0.066, not significant); 2-yr OS 13% vs 3% (p=0.004); PFS HR 0.73 (p=0.001)

Source: PMID 25230595

Timeline

    Guideline citations

    • NCCN SCLC (p.28)
    • CSCO SCLC 2025 (p.67)⚠️ OCR source