PCI99-01

NCT00005062 📎

Regimen

Experimental
Higher-dose PCI 36 Gy (18 fx of 2 Gy QD, or 24 fx of 1.5 Gy BID)
Control
Standard-dose PCI 25 Gy in 10 daily fractions of 2.5 Gy

Population

Limited-stage SCLC in complete remission after chemotherapy and thoracic radiotherapy

Key finding

2-yr brain mets 29% (25 Gy) vs 23% (36 Gy), HR 0.80 (95% CI 0.57-1.11, p=0.18, NS); 2-yr OS 42% vs 37%, HR 1.20 (95% CI 1.00-1.44, p=0.05) favoring 25 Gy; 25 Gy remains standard

Source: PMID 19386548

Timeline

    Guideline citations

    • NCCN SCLC (p.29)