RTOG-0212-HIPPO

NCT01780675 📎

Regimen

Experimental
Hippocampus-avoidance PCI (HA-PCI) 25 Gy in 10 fractions
Control
Standard PCI 25 Gy in 10 fractions

Population

SCLC patients receiving PCI (70% limited-stage in both arms), enrolled Apr 2013 - Mar 2018

Key finding

HVLT-R total recall decline >=5 pts at 4 mo: 29% (PCI) vs 28% (HA-PCI), p=1.000 (NS); OS not different (p=0.43); 2-yr brain mets 20% (PCI) vs 16% (HA-PCI)

Source: PMID 33545387

Timeline

    Guideline citations

    • NCCN SCLC (p.33)
    • CSCO SCLC 2025 (p.55)⚠️ OCR source