SLOTMAN-PCI-2007

NCT00016211 📎

Regimen

Experimental
Prophylactic cranial irradiation (PCI)
Control
No further therapy (observation)

Population

Patients age 18-75 with extensive-stage SCLC who responded to chemotherapy

Key finding

1-yr risk of symptomatic brain metastases 14.6% vs 40.4% (HR 0.27, 95% CI 0.16-0.44, P<0.001); mOS 6.7 vs 5.4 mo; 1-yr OS 27.1% vs 13.3%

Source: PMID 17699816

Timeline

    Guideline citations

    • NCCN SCLC (p.32)
    • CSCO SCLC 2025 (p.75)⚠️ OCR source